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易拉罐封口机|易拉罐灌装封口机|饮料生产线|饮料生产线厂家|液氮加注机|液氮机|饮料设备厂家 • 抗体“鸡尾酒”可延迟猴子感染艾滋病
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抗体“鸡尾酒”可延迟猴子感染艾滋病

发表于 : 周五 4月 29, 2016 1:25 am
jinqijixie








本周在线发表于《自然》的一篇论文显示,单次注射针对艾滋病病毒(HIV)的抗体可以保护猴子在近6个月中不受该病毒的猿猴版本——猴/人免疫缺陷病毒嵌合体(SHIV)的感染。这项研究提供了防治HIV-1病毒的一个概念验证,可能对于抑制艾滋病在高危人群中的传播有重要意义。

动物在接触到高剂量病毒前的一到两天内如果获得了从感染了HIV-1病毒的患者体内提取的抗体,就能显示出阻挡病毒感染的能力,这一点已经被证实。然而,这种被动免疫方法的长期有效性还没被测试过。

对于甲肝的被动免疫方法能在获得有效疫苗前给人提供几个月的保护,基于这个想法,美国马里兰州国立变态反应与感染性疾病研究所Malcolm Martin和同事研究了单次注射有效HIV抗体是否能提供类似的长时间保护。作者在对照组的9只猕猴身上模拟了人类传染HIV的方式,检测到感染的平均时间是3周。

然后,他们向每组6只的3组动物注射1剂3种不同的抗体,然后将它们暴露在病毒中1周。所有接受抗体组的病毒感染都被延迟了,最长的保护持续了23周。保护的持续时间直接与抗体的强度和半衰期相关。该研究小组同时发现能通过在氨基酸中引入变异的方法延长效力最弱的抗体的半衰期。

作者认为组合这类抗体能改善它们整体阻断耐药型HIV-1病毒毒株传播的能力。然而,还需要更多的实验去验证这种方案是否能在人身上有效替代HIV-1疫苗。